Evandro F. Fang, Ph.D. (CUHK), PI (2017.10-present)
Emails: evandrofeifang[at]yahoo.com; e.f.fang[at]medisin.uio.no
Evandro is a molecular gerontologist and runs a research lab aimed at understanding the molecular mechanisms of human aging. His team uses the bench-top knowledge to guide the development of novel interventional strategies towards human aging, with a final goal to improve the quality of life in the elderly. He is passionate about teaching and training junior scientists.
Hobbies: Badminton; Soccer; Hiking; Cycling.
Yahyah Aman, Ph.D. (King´s College London), Postdoc Fellow (2018-present)
Yahyah has investigated mechanisms of pain in Alzheimer’s disease during his PhD programme, under the supervision of Professor Marzia Malcangio and Professor Clive Ballard at King’s College London, UK. In the Fang laboratory, he is interested in investigating the molecular mechanisms of mitochondrial autophagy (mitophagy) and its roles in human aging and age-related neurodegeneration, especially in Alzheimer’s disease. In particular, he is using multiple laboratory models, including human iPCSs, C. elegans, novel transgenic mouse models, as well as human samples, in order to elucidate the molecular mechanisms underlying mitophagy in Alzheimer’s disease.
Hobbies: Football; Cricket.
Sofie H. Lautrup, Ph.D. (Aarhus University), Postdoc Fellow (2018-present)
During her PhD program, Dr. Lautrup studied the connections between the DNA repair pathway base excision repair (BER) and cognitive capacity during aging and disease, under the supervision of Associated Professor Tinna Stevnsner at Aarhus University, Denmark. In addition, she has worked with premature aging, by characterizing two Danish patients suffering from Cockayne Syndrome (MAD 2018). Dr. Lautrup also worked in the laboratory of Dr. Vilhelm A. Bohr at National Institute on Aging, Baltimore, USA during her PhD programme. At NIA, she examined the effect of treatment with the NAD+ precursor Nicotinamide Riboside (NR) on different Alzheimer’s disease (AD) mouse models, including a DNA repair deficient AD mouse model (PNAS 2018). Furthermore, she worked on elucidating the effects of treatments with mitophagy-inducing compounds on an AD mouse model. In the Fang laboratory, she is very interested in studying how NAD+ supplementation affects features seen during both normal aging and premature aging including reduced stem cell proliferation and premature senescence. Dr. Lautrup will utilize fly-models (Drosophila Melanogaster) of the premature aging disorder Werner Syndrome (WS), in addition to C. elegans and human iPSCs, to elucidate how WS patients show reductions of stem cells and how this is related to compromised mitophagy.
Hobbies: Hiking/exploring the nature, being a scout, hanging out with friends/family.
Guofeng Lou, Ph.D. (Ji-nan University), Postdoc Fellow (2018-present)
Dr. Lou studied the molecular mechanisms of modified rhaFGF, which was mediated by the phosphorylation of GSK3β, as a therapeutic strategy for Alzheimer’s disease (AD) in his Ph.D programme, under the supervision of Prof. Yadong Huang at Jinan University, China. He then investigated the role of VAAT and the interplay between VAAT and 5-HT in gene knock-out mouse brain tissues during his first Postdoctoral research, under the supervision of Prof. Klas Kullander at Uppsala University, Sweden. In the Fang laboratory, he is very interested in studying the molecular mechanisms of mitochondrial autophagy (mitophagy) and its roles in AD. More specifically, he is using multiple laboratory models, including C. elegans, novel transgenic mouse models, as well as human iPSCs, to elucidate the molecular basis of impaired mitochondrial motility and defective mitophagy in AD, and to explore the effects of upregulating mitophagy on AD pathology.
Hobbies: Soccer; Swimming; Hiking; Photography
Chenglong Xie, Ph.D. (Shanghai Jiaotong U.), Postdoc Fellow (2019-present)
Dr. Chenglong Xie obtained his Ph.D. in Neurology in 2016 from Shanghai Jiaotong University, China. During his Ph.D. period, he investigated the molecular mechanism of L-dopa-induced dyskinesia (LID) in Parkinson’s disease; more specifically, he studied the novel interactions between CaMKIIa and GluN2B in LID. After his Ph.D., he started a job as a physician scientist in Wenzhou Medical University where he continued his interests in Parkinson’s disease. At UiO, he will be working on the interconnected crosstalk among mitophagy, NAD+, and cognition in Alzheimer’s disease.
Hobbies: Badminton; Basketball; Movie; Reading
Maria Jose Donate Lagartos, Ph.D. (University of Castilla-La Mancha), Postdoc Fellow (2019.11-present)
I did my Ph.D. with Prof. Ricardo Insausti at the University of Castilla-La Mancha, working on the characterization of age-dependent changes in the interneuron populations in the hippocampus of two murine models, SAMP8 and Pol mu mice. Later, I become a postdoctoral fellow in Prof. Menno Witter`s group at the Kavli Institute for Systems Neuroscience/Centre for Neural Computation in Trondheim (Norway), NTNU. The research project I carried out in this laboratory was focused on the postnatal development of the postrhinal cortex to the medial entorhinal cortex projection. During my years as a Ph.D. student and a post-doc, I learnt anatomy, intracellular injections, tracing, and several electrophysiological approaches including anterograde tracing, intracellular injections, confocal imaging, VSD-imaging, patch-clamp, and optogenetics. Currently, I am a postdoctoral fellow in Dr. Evandro F. Fang laboratory and I am interested in studying lysosome pathway in Alzheimer´s disease (AD) by the use of a unique cross-species platform, involving C. elegans, mouse models and human iPSCs.
Hobbies: Reading; Hiking; Movies; Tai-chi; Martial arts.
Johannes Frank, ERASMUS student (2019-present)
Mr. Johannes Frank is an exchange student from the University of Applied Sciences in Krems, Austria. Natural sciences are one of his greatest interests, especially molecular biology and the synergetic interactions of biomolecules in the cell. He will write his Bachelor thesis about the research during his six months internship in the Fang group. In the Fang laboratory he is involved in studying the anti-aging effect of NAD+ precursors on premature aging, especially in the Werner syndrome, using the model organisms Drosophila melanogaster and C. elegans. After finishing his bachelor’s degr, he plans to make a master’s degree in Medical and Pharmaceutical Biotechnology.
Hobbies: skiing, fencing, weight training.
Amund Hov, Volunteer, NO-Age editor (2019.01-present)
Amund is a life-long learner with a passion for the biology of aging. He has a background in applied physics and integrated circuits from the semiconductor industry. Currently he studies and invests in bioscience with the aim of translation into happy and healthy lives.
Hobbies: Rock Climbing, Cooking, Films
Ruben Gudmundsrud, Volunteer, NO-Age editor (2018.07-present), Master student (2019.11-present)
Ruben holds a bachelor’s degree in molecular biology from UiO, and is now taking master courses in immunology and introductory computer science. He works as a scientific assistant (technician, UiO) and editor for the Norwegian Center for Healthy Ageing (NO-Age), and has a special interest in the molecular mechanisms of aging. He thinks exploring the mechanisms can lead to the development of novel therapeutics to suppress the aging phenotype – more importantly to ameliorate disease associated with aging. If we find ways to live longer, we also need to prolong our healthspan. Ruben also has experience from various labs with specialization in neuroscience and immunology.
Hobbies: Hiking/exploring nature, reading, programming, writing, popular science, coffee and TV shows.
Brian Christopher Gilmour, Volunteer, NO-Age editor (2019.01-present)
Brian holds a bachelor’s degree from Canada and is pursuing a master’s in immunology at UiO. He works as a volunteer journalist and editor for the Norwegian Centre for Healthy Ageing (NO-Age) while also completing his thesis at Oslo’s Rikshospitalet, focusing on work with cancer vaccines. Brian has a keen interest in the processes of ageing that started as an undergraduate in Canada and continues here in Norway. He has lab work experience related to immunology, pharmacology and biochemistry.
Hobbies: Swimming, writing, reading, coffee & TV shows
Alice R. Ai, Ph.D candidate(2020.07-)
Alice Ruixue Ai studied in oral medicine from Sichuan University, China. During her master period, she investigated the microenvironmental regulation of the progression of oral potentially malignant disorders towards malignancy. In the Fang lab, she is working on the roles of NAD+ in sleep in different animal models of AD, as well as the role of IL-10 in the NAD+-mitophagy axis in AD.
Hobbies: Traditional Chinese painting; yoga.
Pawel Strychalski, internship student (2020.07 – present)
Pawel is a nutrition science student in Gdansk Medical University, Poland. His main focus is the impacts of lifestyle and nutrition on healthspan, especially in cognitive function. He had an internship in Bologna, Italy in the Carla Ferreri Group where he worked on lipidomics, cell membrane composition in health and disease. His lifelong aim is to translate discoveries from basic science to the promotion of human health and longevity.
Hobbies: reading, exercising in nature.
Feature image: Thon Award Ceremony 2020 (poto by EFF)