Evandro F. Fang, Ph.D. (CUHK), PI (2017.10-present)
Emails: evandrofeifang[at]yahoo.com; e.f.fang[at]medisin.uio.no
Evandro is a molecular gerontologist and runs a research lab aimed at understanding the molecular mechanisms of human aging. His team uses the bench-top knowledge to guide the development of novel interventional strategies towards human aging, with a final goal to improve the quality of life in the elderly. He is passionate about teaching and training junior scientists.
Hobbies: Badminton; Soccer; Hiking; Cycling.
Sofie H. Lautrup, Ph.D. (Aarhus University), Postdoc Fellow (2018-present)
During her PhD program, Dr. Lautrup studied the connections between the DNA repair pathway base excision repair (BER) and cognitive capacity during aging and disease, under the supervision of Associated Professor Tinna Stevnsner at Aarhus University, Denmark. In addition, she has worked with premature aging, by characterizing two Danish patients suffering from Cockayne Syndrome (MAD 2018). Dr. Lautrup also worked in the laboratory of Dr. Vilhelm A. Bohr at National Institute on Aging, Baltimore, USA during her PhD programme. At NIA, she examined the effect of treatment with the NAD+ precursor Nicotinamide Riboside (NR) on different Alzheimer’s disease (AD) mouse models, including a DNA repair deficient AD mouse model (PNAS 2018). Furthermore, she worked on elucidating the effects of treatments with mitophagy-inducing compounds on an AD mouse model. In the Fang laboratory, she is very interested in studying how NAD+ supplementation affects features seen during both normal aging and premature aging including reduced stem cell proliferation and premature senescence. Dr. Lautrup will utilize fly-models (Drosophila Melanogaster) of the premature aging disorder Werner Syndrome (WS), in addition to C. elegans and human iPSCs, to elucidate how WS patients show reductions of stem cells and how this is related to compromised mitophagy.
Hobbies: Hiking/exploring the nature, being a scout, hanging out with friends/family.
Guofeng Lou, Ph.D. (Ji-nan University), Postdoc Fellow (2018-)
Dr. Lou studied the molecular mechanisms of modified rhaFGF, which was mediated by the phosphorylation of GSK3β, as a therapeutic strategy for Alzheimer’s disease (AD) in his Ph.D programme, under the supervision of Prof. Yadong Huang at Jinan University, China. He then investigated the role of VAAT and the interplay between VAAT and 5-HT in gene knock-out mouse brain tissues during his first Postdoctoral research, under the supervision of Prof. Klas Kullander at Uppsala University, Sweden. In the Fang laboratory, he is very interested in studying the molecular mechanisms of mitochondrial autophagy (mitophagy) and its roles in AD. More specifically, he is using multiple laboratory models, including C. elegans, novel transgenic mouse models, as well as human iPSCs, to elucidate the molecular basis of impaired mitochondrial motility and defective mitophagy in AD, and to explore the effects of upregulating mitophagy on AD pathology.
Hobbies: Soccer; Swimming; Hiking; Photography
Maria Jose Donate Lagartos, Ph.D. (University of Castilla-La Mancha), Postdoc Fellow (2019.11-)
I did my Ph.D. with Prof. Ricardo Insausti at the University of Castilla-La Mancha, working on the characterization of age-dependent changes in the interneuron populations in the hippocampus of two murine models, SAMP8 and Pol mu mice. Later, I become a postdoctoral fellow in Prof. Menno Witter`s group at the Kavli Institute for Systems Neuroscience/Centre for Neural Computation in Trondheim (Norway), NTNU. The research project I carried out in this laboratory was focused on the postnatal development of the postrhinal cortex to the medial entorhinal cortex projection. During my years as a Ph.D. student and a post-doc, I learnt anatomy, intracellular injections, tracing, and several electrophysiological approaches including anterograde tracing, intracellular injections, confocal imaging, VSD-imaging, patch-clamp, and optogenetics. Currently, I am a postdoctoral fellow in Dr. Evandro F. Fang laboratory and I am interested in studying lysosome pathway in Alzheimer´s disease (AD) by the use of a unique cross-species platform, involving C. elegans, mouse models and human iPSCs.
Hobbies: Reading; Hiking; Movies; Tai-chi; Martial arts.
Johannes Frank, ERASMUS student (2019.06-2020.01 ERASMUS student) (2020.09-present Master student at the University of Vienna, un-officially co-mentoring on his mater project)
Mr. Johannes Frank is an exchange student from the University of Applied Sciences in Krems, Austria. Natural sciences are one of his greatest interests, especially molecular biology and the synergetic interactions of biomolecules in the cell. He will write his Bachelor thesis about the research during his six months internship in the Fang group. In the Fang laboratory he is involved in studying the anti-aging effect of NAD+ precursors on premature aging, especially in the Werner syndrome, using the model organisms Drosophila melanogaster and C. elegans. After finishing his bachelor’s degr, he plans to make a master’s degree in Medical and Pharmaceutical Biotechnology.
Hobbies: skiing, fencing, weight training.
Amund Hov, Volunteer, NO-Age editor (2019.01-)
Amund is a life-long learner with a passion for the biology of aging. He has a background in applied physics and integrated circuits from the semiconductor industry. Currently he studies and invests in bioscience with the aim of translation into happy and healthy lives.
Hobbies: Rock Climbing, Cooking, Films
Ruben Gudmundsrud, Volunteer, NO-Age editor (2018.07-present), Master student (2019.11-2020.11)
Ruben holds a bachelor’s degree in molecular biology from UiO, and is now taking master courses in immunology and introductory computer science. He works as a scientific assistant (technician, UiO) and editor for the Norwegian Center for Healthy Ageing (NO-Age), and has a special interest in the molecular mechanisms of aging. He thinks exploring the mechanisms can lead to the development of novel therapeutics to suppress the aging phenotype – more importantly to ameliorate disease associated with aging. If we find ways to live longer, we also need to prolong our healthspan. Ruben also has experience from various labs with specialization in neuroscience and immunology.
Hobbies: Hiking/exploring nature, reading, programming, writing, popular science, coffee and TV shows.
Brian Christopher Gilmour, Volunteer, NO-Age editor (2019.01-)
Brian holds a bachelor’s degree from Canada and is pursuing a master’s in immunology at UiO. He works as a volunteer journalist and editor for the Norwegian Centre for Healthy Ageing (NO-Age) while also completing his thesis at Oslo’s Rikshospitalet, focusing on work with cancer vaccines. Brian has a keen interest in the processes of ageing that started as an undergraduate in Canada and continues here in Norway. He has lab work experience related to immunology, pharmacology and biochemistry.
Hobbies: Swimming, writing, reading, coffee & TV shows
Shuqin Cao, visiting Ph.D candidate (2020.02-)
Shu holds a bachelor degree from The University of Malaya, Malaysia, and is reading a Ph.D programme in Clinical Biochemistry and Molecular Medicine at the Chulalongkorn University, Thailand. She is working as a visiting student in the Fang lab (UiO) from Feb 2020. Her Ph.D. project is focusing on the identification of potential anti-AD drug candidates from natural molecules isolated from Thai medicine.
Hobbies: Exploring the world, Snorkelling, Hiking, Yoga, Belly dance
Alice R. Ai, Ph.D, Lab engineer and then candidate (2020.07-)
Alice Ruixue Ai studied in oral medicine from Sichuan University, China. During her master period, she investigated the microenvironmental regulation of the progression of oral potentially malignant disorders towards malignancy. In the Fang lab, she is working on the roles of NAD+ in sleep in different animal models of AD, as well as the role of IL-10 in the NAD+-mitophagy axis in AD.
Hobbies: Traditional Chinese painting; yoga.
Tomás Schmauck-Medina, Lab engineer then Ph.D. student (2020.10- )
Tomás is interested in the mechanisms of ageing and age-related neurodegenerative diseases. After his bachelor degree in Biomedicine he went to University College London (UCL) to study Neuroscience and was worked on ageing in the laboratory of Professor Dame Linda Partridge. In UCL, he studied the neuroprotective role of GADD45 in ALS. In the Fang laboratory at the University of Oslo (UiO), he is interested in mechanisms of ageing, autophagy, mitophagy, and how they impact neurodegeneration, with a focus on Alzheimer’s disease. He is using C. elegans, mice, and iPSCs in combination with Crispr and confocal microscopy techniques to address related questions.
Hobbies: Writing, debating, real-time strategy games
Heling Wang (2019.12-)
Heling holds a bachelor degree in Medicine and a master degree in Oral Medicine from Jilin University, China. During her master, she did a one-year intern program in Okayama University, Japan. She got training on microbiota and her research was mainly focused on microbiota related-diseases. In the Fang lab at the University of Oslo (UiO), she is focusing on the mechanistic studies of Alzheimer´s disease(AD), with focuses on ApoE4, NAD+, and autophagy/mitophagy. She will also conduct research on microbiota and AD to address related questions.
Hobbies: Photography, gourmet, swimming, documentary.
Thale Dawn Patrick-Brown, MSc, MIET, PPT, Lab manager (2021.03-)
Thale started her research career last century at the precocious age of 12, when she took up her first post as a summer research assistant, pulling catheters, packing and autoclaving surgical equipment and assisting with things requiring small fingers. Eventually, she graduated from lower school and obtained an honours degree in Neuroscience studying under the profs who literally wrote the book (Kolb and Whishaw), who likely only remember her as that lass whose senior project proposed a neural network for diagnosis of psychiatrically-relevant changes in the brain using fMRI before such things were computationally possible (she got a D). Thale completed an eye-watering three full undergraduate theses in Foetal Physiology, Aerospace Neurophysiology, and 11-Beta Hydroxysteroid Dehydrogenase Type 1&2 in foetal development respectively. Her MSc focused on the use of artificial intelligence to solve chaotic real-world problems, a theme she has continued in her PhD (which she is completing concurrent to work). Thale recently published her first-first-author paper describing a novel statistical methodology for the estimation of prevalence and incidence in rare diseases using Pseudomyxoma peritonei (PMP) as a model (with collaborators from EuroPMP). She has undertaken specialist training in gross anatomy and is interested in the role of the HPA axis in physiological activities, including parturition and metastatic disease. Thale is the Scientific Communications Manager for EuroPMP and a professional medical project manager. She can usually be found staring intently at a computer screen, muttering incoherently about grammar.
Interests: Thale is a licensed race driver and sports therapist, plays polo and is terminally British.
Alexandra Gilbert, PhD candidate (2021.10-)
Ally is deeply fascinated by the relationship between sleep and Alzheimer’s Disease with a focus on mitochondrial metabolism. She is determined to find causal molecular targets linking sleep behaviour and Alzheimer’s disease, inspired by her volunteering work in hospital emergency rooms and psychiatric residences. She graduated from University College London with an MSc in Neuroscience in Prof Jason Rihel’s lab, examining the cellular prion protein’s role in recovery sleep as well as sleep homeostasis and circadian rhythms in zebrafish. Previously, she received a Bachelor of Health Sciences (Honours) degree at the University of the Witwatersrand, South Africa, specialised in Medical Cell Biology. Her skills are immunohistochemistry, time-series data analysis and in vivo behaviour tracking.
Hobbies: Journalism, fiction, poetry, unwarranted puns and hiking.
Caroline Shi-qi Zhang, Ph.D. student (2021.05-)
Caroline has a master of Science degree in the China Medical University, China; during this period she did a one-year intern program in Prof. Clifford Woolf lab at the Harvard Medical School/Boston Children’s Hospital, USA. In Harvard Medical School, her research was mainly on developing an ALS-associated human motor neuron model of mutant ¬TDP-43 for genome-wide CRISPR screens. In the Fang lab at the University of Oslo (UiO), she is focusing on the mechanistic studies of Alzheimer´s disease(AD), with focuses on ApoE4, NAD+, and autophagy/mitophagy. She uses a cross-species approach, covering human iPSC-derived neurons and glial cells, nematodes, mice, and postmortem brain tissues from individuals affected with AD to address related questions.
Hobbies: TV shows, writing.
Ole Kristian Reiten, Medical student (2020.03-)
Ole Kristian is a Norwegian medical student at the University of Oslo (UiO). Here, he is currently attending his fourth year at the faculty of medicine, where he was granted the possibility to write his project thesis at the Fang lab in collaboration with Martin Andreas Wilvang. He is particularly interested in the development of potential interventional strategies to mitigate neurodegenerative and age-related disease phenotypes as the global population continuously grows older. His contributions at the lab revolves around exploring the therapeutic potential of NAD+ boosting to forestall these phenotypes and promote healthy longevity.
Hobbies: Callisthenics, exploring the world, fiction, playing the guitar
Martin Andreas Wilvang, Medical student (2020.03-)
Martin is a norwegian medical student at the University of Oslo on his fourth year and finds the field of neurodegenerative diseases and the potential of NAD+ boosting to mitigate neurodegenerative phenotypes especially interesting. He became a part of the Fang lab through working on a master’s equivalent subject at the university along with Ole Kristian. He has been writing a review about “Preclinical and clinical evidence of NAD+ precursors in health and ageing” with a focus on the pharmacological aspects of different precursors.
Hobbies: Bible studies and teaching, skiing, climbing and volleyball